Synthroid Levothyroxine Sodium: Side Effects, Uses, Dosage, Interactions, Warnings

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Synthroid Levothyroxine Sodium: Side Effects, Uses, Dosage, Interactions, Warnings

Levoxyl treats hypothyroidism (low thyroid hormone) and treats or prevents goiter. NP Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid cancer … Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Levothyroxine is also used in adults along with surgery and radioactive iodine therapy to treat a certain type of thyroid cancer. Adequate therapy usually results in normal TSH and T4 levels after 2 to 3 weeks of therapy. All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory Agency using the Yellow Card Scheme.

AMERICA’S #1 PRESCRIBED BRANDED HYPOTHYROIDISM MEDICATION1,2*

Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. The general aim of therapy is to normalize the serum TSH level. TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of SYNTHROID see Warnings and Precautions (5.1) and Use in Specific Populations (8.4).

Use our dose calculator for adults

Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination. The liver is the major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including the kidney and other tissues. Approximately 80% of the daily dose of T4 is deiodinated to yield equal amounts of T3 and reverse T3 (rT3). Thyroid hormones are also metabolized via conjugation with glucuronides and sulfates and excreted directly into the bile and gut where they undergo enterohepatic recirculation. SYNTHROID may reduce the therapeutic effects of digitalis glycosides.

​Inquire whether patients are taking biotin or biotin-containing supplements. If so, advise them to stop biotin supplementation at least 2 days before assessing TSH and/or T4 levels. Check with your doctor right away if you have weakness, confusion or non-responsiveness, feeling cold, low body temperature, swelling of the body, especially the face, tongue, and lower legs, or difficulty breathing. These could be symptoms of severe hypothyroidism, called myxedema coma, which may be life-threatening and requires immediate medical attention.

  • Some brands of levothyroxine have different dosage instructions and/or recommendations of how soon you need to take them before eating food.
  • Generally, thyroid replacement treatment is to be taken for life.
  • This includes prescription and over-the-counter medicines, vitamins, and herbal products.

Armour Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid … This is not a complete list of side effects and others may occur. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels.

Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased. Closely monitor coagulation tests to permit appropriate and timely dosage adjustments. SYNTHROID is indicated in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent buy synthroid well-differentiated thyroid cancer. In acute, emergency conditions, injectable levothyroxine sodium (T4) may be given intravenously when oral administration is not feasible or desirable, as in the treatment of myxedema coma, or during total parenteral nutrition. Intramuscular administration is not advisable because of reported poor absorption.

Stop biotin and biotin-containing supplements for at least 2 days before assessing TSH and/or T4 levels see DRUG INTERACTIONS. Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of Synthroid.

Foods containing soy and cottonseed meal can make Synthroid less effective. Walnuts, grapefruit juice, and dietary fiber can also make Synthroid less effective. If you eat any of these on a regular basis, check with your doctor.

Adequate levothyroxine treatment during lactation may normalize milk production in hypothyroid lactating mothers with low milk supply. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID see CONTRAINDICATIONS. Titrate the dose of SYNTHROID carefully and monitor response to titration to avoid these effects see DOSAGE AND ADMINISTRATION. Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see DOSAGE AND ADMINISTRATION, DRUG INTERACTIONS and CLINICAL PHARMACOLOGY. Toxic effects may include increased risk of cardiac arrhythmias and central nervous system stimulation.

3 Oral Anticoagulants

Check with your physician for additional information about side effects. Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain. Get medical help right away, if you have any of the symptoms listed above.